Core Technologies for ChemBioIT Roadmap: Shortlist
1. MOLECULAR COMPUTING & TEMPLATE CHEMISTRY
- Systems Chemistry, Supramolecular and Synthetic Chemistry
The main target is to use molecular information to direct autonomous synthesis that replicates this information via supramolecular complexes and the systems’ kinetics. Already, in the absence of other information mechanisms (e.g. biochemical enzymes), simple chemical information in various small organic molecules can be replicated synthetically.
- DNA computing and DNA machines
The main target is to use DNA to direct assembly of complex structures and the operation of molecular machines. The considerable sequence programmability makes progress towards autonomous fabrication in this area significant, including directing the assembly of other nanoscale and even microscale objects.
- Inorganic biology and genetic alternatives to nucleic acids
The ability to build complex combinatorial structures in for example polyoxometalates and replicate structural variations thereof opens interesting possibilities to develop a self-informed inorganic autonomous fabrication that can already span spatial scales (e.g. in tube structures).
- Artificial chemistries and formalisms for molecular construction and IT
Research on algorithms and architectures for organizing molecular construction as an information process single out particular chemical mechanisms and properties (e.g. chemical organizations, sensitivity analysis) that highlight important targets for experimental work on building molecular systems that unite construction and information processing.