Researcher: Dr Jamie Twycross
Dr Jamie Twycross is a Senior Research Fellow at the University of Nottingham based in the Interdisciplinary Computing and Complex Systems (ICOS) group. He has a background in computer science, biology and mathematical physics with research experience in both academic and corporate institutions.
He has developed novel computational techniques based on biology (biologically-inspired computing), and developed and applied cutting-edge computational methods to address biological problems (synthetic/systems/computational biology).
He is currently lead on the EPSRC-funded ROADBLOCK project. ROADBLOCK is an application-driven research project seeking to integrate the creation of new computational algorithms, tools and theories for synthetic biology with well-established wet lab techniques to develop an integrated and validated software suite for synthetic biology.
Full Research Profile »
1. The Infobiotics Workbench: an Integrated In Silico Modelling Platform for Systems and Synthetic Biology. Jonathan Blakes, Jamie Twycross, Francisco Romero-Campero and Natalio Krasnogor. Bioinformatics, 27(23):3323-3324, 2011.
2. A Thermodynamic Switch Modulates Abscisic Acid Receptor Sensitivity. Florine Dupeux, Julia Santiago, Katja Betz, Jamie Twycross, Sang-Youl Park, Lesia Rodriguez, Miguel Gonzalez-Guzman, Malene Jensen, Natalio Krasnogor, Michael Holdsworth, Martin Blackledge, Sean Cutler, Pedro Rodriguez and Jose Marquez. EMBO Journal, 30:4171-4184, 2011.
3. Stochastic and Deterministic Multiscale Models for Systems Biology: an Auxin-Transport Case Study. Jamie Twycross, Leah R. Band, Malcolm J. Bennett, John R. King and Natalio Krasnogor. BMC Systems Biology, 4(1):1-34, 2010.
4. Detecting Anomalous Process Behaviour using Second Generation Artificial Immune Systems. Jamie Twycross, Uwe Aickelin and Amanda Whitbrook. International Journal of Unconventional Computing, 6(3-4):301-326, 2010.
5. Implementing and Testing a Virus Throttle. Jamie Twycross and Matthew Williamson. Proc. of the 12th USENIX Security Symposium, p.285-294, Washington, D.C., August 2003.
Paper: Full Design Automation of Multi-State RNA Devices to Program Gene Expression Using Energy-Based Optimization
Rodrigo, G., Landrain, T.E., Majer, E., Daròs, J-A., and Jaramillo, A.
A new BACTOCOM paper has appeared in PLOS Computational Biology.
BACTOCOM is one of the projects closely linked with COBRA.
PLoS Computational Biology 9(8): e1003172. doi:10.1371/journal.pcbi.1003172
Read the full paper (open access) »
Synthetic biology - no bars to progress
In March, the COBRA coordinator Martyn Amos visited a slightly unusual venue in order to spread the word about synthetic biology. Run by the British Science Association, monthly “SciBar” meetings do exactly what their name suggests – provide a forum for discussing science, in a bar!
Martyn returned to Liverpool, a city in which he spent six years working, first as a post-doc and then as a lecturer in biosystems and informatics.
In his talk, Martyn drew on his 2006 book Genesis Machines: The New Science of Biocomputing to give an overview of the current state-of-the-art in synthetic biology. Despite competition from a Champions League match on live TV, the talk attracted a healthy-sized audience, and it was followed by a lively question and answer session.
Photograph: John Bradley: The Ship and Mitre, the venue for Liverpool SciBar.